Therapy of Autologous Human Adipose Tissue-Derived Mesenchymal Stem cells for the Cerebral Palsy: A Case Report

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Abstract

This case report describes the efficacy of intravenous administration of autologous human adipose tissue-derived mesenchymal stem cells(hAdMSCs) in a female patient aged 28 years and 7 months with cerebral palsy. Our group previously demonstrated the in vitro differentiation capacity of hAdMSCs into adipocytes, osteoblasts and neuronal cells. This case was conducted as compassionated stem cell therapy.

Subcutaneous fatwas collected from the patient’s abdomen vialiposuction. Isolation and cultivation of the hAdMSCs was performed as previously described. The immune phenotype and karyotype of the hAdMSCs was evaluated, followed by confirmation of their differentiation potential in vitro. Clinical examinations were performed immediately before  and 1year after the first stem cell intravenously infusion at intervals of 3 months, and  included the following tests:1)the Gross Motor Function Measure;2) the Oral Motor  Function Assessment;3) the Urimal Test of Articulation and Phonology;4) the Korean  Developmental Test of Visual Perception-2; and 5) the Kaufman Assessment Battery for Children.

The patient did not have any adverse reactions during intravenous infusion of autologous hAdMSCs or at post-treatment follow-up. Gross motor function and the motor function of the tongue, jaw, and lip,all showed noticeable improvements. In particular,the motor function of  the tongue was markedly increased by hAdMSC administration, leading to enhanced articulation skills post-infusion. The patient also showed improvement in the visual motor  integration and general visual perception categories of theK-DTVP-2. In addition, her acquired learning skills as assessed by the Kaufman Assessment Battery for Children, were significantly increased.

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