Immunodeficiencies

SCID

1. The process of killing a bacteria using what is called the oxygen-dependent respiratory burst is a mechanism of what type of cells?

A. T
B. B
C. Neutrophils
D. APCs
E. Both B & T

2. The alternative pathway of the complement system is activated by:

A. antigen-antibody reactions
B. polysaccharides from yeasts and gram-negative bacteria
C. none of the above
D. Both A & B

3. After processing, the MHC molecules display the short amino acid sequences derived from the antigen by different classes of T cells.
Class 1 pairs with:

A. CD8+
B. CD4+
C. CD 40 Ligand
D. CD 22

4. In Hyper-IgM Syndrome, there is a defect that affects class switching of antibodies. IgM levels are high,
while IgG, IgA and IgE levels are significantly depressed or absent.
This occurs becuase T cells are unable to produce:

A. CD8+
B. TCR
C. CD40 Ligand
D. CD 28/CTLA4

5. The second most common form of SCID leads to accumulation of adenosine, 2’-deoxyadenosine, and 2’-O-methyladenosine,
all of which are toxic to T cells and cause T cell apoptosis.
This is caused by a deficiency in:

A. NADPH oxidase
B. adenosine deaminase
C. MAC complex

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